David Sinclair
Biology of Aging and Longevity
Aging is simultaneously the most universal human experience and one of the least understood biological processes. Every human being ages, yet the fundamental mechanisms driving the progressive decline in physiological function, the increasing vulnerability to disease, and the ultimate limit on...
Senolytics, NAD+, and the New Science of Longevity
Inside your body right now, there are cells that have stopped dividing but refuse to die. They sit in your tissues — fat, skin, joints, lungs, blood vessels — secreting a toxic cocktail of inflammatory molecules, tissue-degrading enzymes, and growth factors that corrupt their neighbors.
Mitochondrial Optimization Protocol
Two billion years ago, a primitive cell swallowed a bacterium. Instead of digesting it, the two formed an alliance.
Caloric Restriction: The Most Ancient Longevity Mechanism and Its Consciousness Connection
Long before rapamycin was extracted from Easter Island soil, long before NAD+ was identified as a coenzyme, long before anyone knew what a telomere was, one intervention had already been shown to extend lifespan more consistently than any other: eating less.
Epigenetic Clocks: Measuring Biological Age and the Consciousness-Aging Connection
You have two ages. The first is chronological — the number of years since your birth, ticking forward at exactly the same rate for everyone, indifferent to how you live.
NAD+ and Sirtuins: The Cellular Energy Currency of Longevity and Consciousness
Imagine your body as a massive data center — trillions of processors running simultaneously, each requiring a constant power supply. Now imagine that the power grid feeding this data center loses approximately 50% of its capacity between ages 40 and 60.